Stimulation of a Suprachoroidal Retinal Prosthesis Drives Cortical Responses in a Feline Model of Retinal Degeneration
نویسندگان
چکیده
منابع مشابه
First-in-Human Trial of a Novel Suprachoroidal Retinal Prosthesis
UNLABELLED Retinal visual prostheses ("bionic eyes") have the potential to restore vision to blind or profoundly vision-impaired patients. The medical bionic technology used to design, manufacture and implant such prostheses is still in its relative infancy, with various technologies and surgical approaches being evaluated. We hypothesised that a suprachoroidal implant location (between the scl...
متن کاملFeline central retinal degeneration.
Seven domestic cats with feline central retinal degeneration (FCRD) were investigated by ophthalmoscopy, fluorescein angiography, electroretinography, and light and electron microscopy. Little or no increase in lesion size was observed ophthalmoscopically over periods as long as four years. Five cats showed normal rod electroretinographic (ERG) responses and abnormal cone responses. In one cat ...
متن کاملFactors affecting perceptual thresholds in a suprachoroidal retinal prosthesis.
PURPOSE The suprachoroidal location for a retinal prosthesis provides advantages over other locations in terms of a simplified surgical procedure and a potentially more stable electrode-neural interface. The aim of this study was to assess the factors affecting perceptual thresholds, and to optimize stimulus parameters to achieve the lowest thresholds in patients implanted with a suprachoroidal...
متن کاملChronic Electrical Stimulation with a Suprachoroidal Retinal Prosthesis: A Preclinical Safety and Efficacy Study
PURPOSE To assess the safety and efficacy of chronic electrical stimulation of the retina with a suprachoroidal visual prosthesis. METHODS Seven normally-sighted feline subjects were implanted for 96-143 days with a suprachoroidal electrode array and six were chronically stimulated for 70-105 days at levels that activated the visual cortex. Charge balanced, biphasic, current pulses were deliv...
متن کاملDevelopment of a surgical procedure for implantation of a prototype suprachoroidal retinal prosthesis
BACKGROUND Current surgical techniques for retinal prosthetic implantation require long and complicated surgery, which can increase the risk of complications and adverse outcomes. METHOD The suprachoroidal position is known to be an easier location to access surgically, and so this study aimed to develop a surgical procedure for implanting a prototype suprachoroidal retinal prosthesis. The ar...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2016
ISSN: 1552-5783
DOI: 10.1167/iovs.16-19926